北海道大学 先端生命科学研究院上原研究室

Uehara Lab, Faculty of Advanced Life Science, Hokkaido University

Articles


2020

Research Article

 

Koya Yoshizawa, Kan Yaguchi, and Ryota Uehara* (*corresponding author)

Uncoupling of DNA replication and centrosome duplication cycles is a primary cause of haploid instability in mammalian somatic cells

Frontiers in Cell and Developmental Biology (2020) 8:721 https://doi.org/10.3389/fcell.2020.00721

 

Noushaba Mafy, Kazuya Matsuo, Shota Hiruma, Ryota Uehara*, and Nobuyuki Tamaoki* (*co-corresponding author)

Photoswitchable CENP-E inhibitor enabling the dynamic control of chromosome movement and mitotic progression

Journal of the American Chemical Society (2020)142:1763-1767 Full Text

DOI: 10.1021/jacs.9b12782

Preprint

Koya Yoshizawa, Kan Yaguchi, and Ryota Uehara* (*corresponding author)

Uncoupling of DNA replication and centrosome duplication cycles is a primary cause of haploid instability in mammalian somatic cells

BioRχiv doi: https://doi.org/10.1101/2020.05.30.124826

2018

Research Article

 

Yaguchi, K.Yamamoto, T., Matsui, R.Shimada, M., Shibanuma, A., Kamimura, K., Koda, T., and Uehara, R.* (*corresponding author)

Tetraploidy-Associated Centrosome Overduplication in Mouse Early Embryos

Communicative & Integrative Biology (2018) e1526605-1-e1526605-4 [Full text (via HUSCAP)]

 

Yaguchi, K.#, Yamamoto, T.#, Shimada, M.#, Sugimoto, R.#, Nakamura, K., Ayabe, T., and Uehara, R.(*corresponding author; # equally contributed)

Ploidy-dependent change in cyclin D2 expression and sensitization to cdk4/6 inhibition in human somatic haploid cells

Biochemical and Biophysical Research Communications (2018) 504(1):231-237 [Journal site]

 

Yaguchi, K., Yamamoto, T.#Matsui, R.#Tsukada, Y., Shibanuma, A., Kamimura, K., Koda, T., and Uehara, R.* (*corresponding author; # equally contributed)

Uncoordinated centrosome cycle underlies the instability of non-diploid somatic cells in mammals

Journal of Cell Biology (2018) 217: 2463-2483 [Journal site] [Press release][Full text (via HUSCAP)]

 

2017

Research Article

Hiruma, S., Kamasaki, T., Otomo, K., Nemoto, T., and Uehara, R.* (*corresponding author)

Dynamics and function of ERM proteins during cytokinesis in human cells

FEBS Letters 591: 3296-3309(2017) Full text

Preprint

Kan Yaguchi, Ryo Matsui, Takahiro Yamamoto, Yuki Tsukada, Atsuko Shibanuma, Keiko Kamimura, Toshiaki Koda, and Ryota Uehara* (*corresponding author)

Uncoordinated centrosome duplication cycle underlies the instability of non-diploid states in mammalian somatic cells

BioRχiv doi: https://doi.org/10.1101/194746

2016

Research Article

Uehara, R.*, Kamasaki, T., Hiruma, S., Poser, I., Yoda, K., Yajima, J., Gerlich, D.W., and Goshima, G. (*corresponding author)

Augmin shapes the anaphase spindle for efficient cytokinetic furrow ingression and abscission.

Molecular Biology of the Cell  1; 27; 812-827 (2016)

Full text (via HUSCAP)

2015 以前

Research Article

Uehara, R.*, Tsukada, Y., Kamasaki, T., Poser, I., Yoda, K., Gerlich, D.W., and Goshima, G.* (*co-corresponding authors)

Aurora B and Kif2A control microtubule length for assembly of a functional central spindle during anaphase.

Journal of Cell Biology 202:623-636 (2013) (Article)

 

Nakaoka, Y., Miki, T., Fujioka, R., Uehara, R., Tomioka, A., Obuse, C., Kubo, M., Hiwatashi, Y., and Goshima, G.

An inducible RNAi system in Physcomitrella patens reveals a dominant role of augmin in phragmoplast microtubule generation.

Plant Cell  24:1478-1493 (2012)

 

Uehara, R. and Goshima, G.

Functional central spindle assembly requires de novo microtubule generation in the interchromosomal region during anaphase.

Journal of Cell Biology 191: 259-267 (2010)

 

Uehara, R., Goshima, G., Mabuchi, I., Vale, R.D., Spudich, J. A., Griffis, E. R.

Determinants of myosin II cortical localization during cytokinesis.

Current Biology 20: 1080-1085 (2010)

 

Uehara, R., Nojima, R., Tomioka, A., Petry, S., Vale, R., Obuse, C., and Goshima, G.

The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells.

Proc Natl Acad Sci USA 106: 6998-7003 (2009)

 

Uehara, R., Hosoya, H., and Mabuchi, I.

In vivo phosphorylation of regulatory light chain of myosin II in sea urchin eggs and its role in controlling myosin localization and function during cytokinesis.

Cell Motility and Cytoskelton 65: 100-115 (2008)