- # ?>Our target, the ventromedial nucleus of the hypothalamus (VMH, green; cfos, red)
- # ?>Mitochondrial morphological dynamics is critical factor in glucose sensing
- # ?>Neurons in the brain stem (Green, NeuN; Blue, DAPI; Red, pS6)
- # ?>Neuronal projection (green) from the VMH to the midbrain neuron (red)
- # ?>Confocal image of the activated neuron stained with cfos (red) in the VMH neuron (green)
We investigate the following questions
- How does our brain keep blood glucose levels normal?
- What are the neurons and neuronal circuitry to regulate peripheral glucose metabolism?
- What is the molecular mechanism to regulate glucose sensing by hypothalamic neurons?
- What is the cause of diabetes?
The research goal of my team is to understand the brain for the homeostatic control of whole body glucose metabolism. Its dysregulation can lead to the development of diabetes. Our interests include brain nutrient sensing, food intake, the neuronal circuitry from hypothalamus to peripheral tissues, mitochondrial dynamics and the changes of them in the diabetic and obese mouse models.
Our target region is the ventromedial hypothalamus (VMH), in which both glucose excited and inhibited neurons exist. By using optogenetics and Crispr/Cas9 system, we investigate the role of VMH projections and molecules in the VMH neuron in the control of glucose metabolism in the liver and muscle, glucose sensing, food intake and development of diabetes.
VMH and Insulin Sensitivity
The Toda lab is seeking a highly-motivated candidate for PhD student.