橋本大吾

Daigo HASHIMOTO

school icon

助教, M.D., Ph.D.

school icon

北海道大学 医学研究科

mail icon

D5hash [at] pop.med.hokudai.ac.jp


業績

[英語論文]

  1. Uryu H, Hashimoto D, Kato K, Hayase E, Matsuoka S, Ogasawara R, Takahashi S, Maeda Y, Iwasaki H, Miyamoto T, Saijo S, Iwakura Y, Hill GR, Akashi K, Teshima T. Alpha-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice. Blood. 2015 Online.
  2. Moskalenko M, Pan M, Fu Y, de Moll EH, Hashimoto D, Mortha A, Leboeuf M, Jayaraman P, Bernardo S, Sikora AG, Wolchok J, Bhardwaj N, Merad M, Saenger Y. Requirement for Innate Immunity and CD90+ NK1.1- Lymphocytes to Treat Established Melanoma with Chemo-Immunotherapy. Cancer Immunol Res. 2015, 3, 296-304.
  3. Muller PA, Koscsó B, Rajani GM, Stevanovic K, Berres ML, Hashimoto D, Mortha A, Leboeuf M, Li XM, Mucida D, Stanley ER, Dahan S, Margolis KG, Gershon MD, Merad M, Bogunovic M. Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility. Cell. 2014, 158: 300-13.
  4. Mortha A, Chudnovskiy A, Hashimoto D, Bogunovic M, Spencer SP, Belkaid Y, Merad M. Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Science. 2014, 343: 1249288.
  5. Shiratori S, Fujimoto K, Nishimura M, Hatanaka KC, Kosugi-Kanaya M, Okada K, Sugita J, Shigematsu A, Hashimoto D, Endo T, Kondo T, Abe R, Hashino S, Matsuno Y, Shimizu H, Teshima T. Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning for mycosis fungoides and Sezary syndrome. Hematol Oncol. On line
  6. Iwasaki J, Kondo T, Darmanin S, Ibata M, Onozawa M, Hashimoto D, Sakamoto N, Teshima T. FIP1L1 presence in FIP1L1-RARA or FIP1L1-PDGFRA differentially contributes to the pathogenesis of distinct types of leukemia. Ann Hematol. 2014, 93: 1473-81.
  7. Shiratori S, Wakasa K, Okada K, Sugita J, Akizawa K, Shigematsu A, Hashimoto D, Fujimoto K, Endo T, Kondo T, Shimizu C, Hashino S, Teshima T. Stenotrophomonas maltophilia infection during allogeneic hematopoietic stem cell transplantation: a single-center experience. Clin Transplant. 2014, 28: 656-61.
  8. Jiao J, Dragomir AC, Kocabayoglu P, Rahman AH, Chow A, Hashimoto D, Leboeuf M, Kraus T, Moran T, Carrasco-Avino G, Friedman SL, Merad M, Aloman C. Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils. J Immunol. 2014, 192: 3374-82.
  9. Shono Y, Shiratori S, Kosugi-Kanaya M, Ueha S, Sugita J, Shigematsu A, Kondo T, Hashimoto D, Fujimoto K, Endo T, Nishio M, Hashino S, Matsuno Y, Matsushima K, Tanaka J, Imamura M, Teshima T. Bone marrow graft-versus-host disease: evaluation of its clinical impact on disrupted hematopoiesis after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2014 20: 495-500.
  10. Agudo J, Ruzo A, Tung N, Salmon H, Leboeuf M, Hashimoto D, Becker C, Garrett-Sinha LA, Baccarini A, Merad M, Brown BD. The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids. Nat Immunol. 2014, 15: 54-62.
  11. Koyama M, Hashimoto D, Nagafuji K, Eto T, Ohno Y, Aoyama K, Iwasaki H, Miyamoto T, Hill GR, Akashi K, Teshima T. Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning. Bone Marrow Transplant. 2014 Jan;49(1):110-5.
  12. Eriguchi Y, Uryu H, Nakamura K, Shimoji S, Takashima S, Iwasaki H, Miyamoto T, Shimono N, Hashimoto D, Akashi K, Ayabe T, Teshima T. Reciprocal expression of enteric antimicrobial proteins in intestinal graft-versus-host disease. Biol Blood Marrow Transplant. 2013, 19: 1525-9
  13. Bongers G, Pacer ME, Geraldino TH, Chen L, He Z, Hashimoto D, Furtado GC, Ochando J, Kelley KA, Clemente JC, Merad M, van Bakel H, Lira SA. Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice. J Exp Med. 2014, 211: 457-72.
  14. Hashimoto D, Chow A, Noizat C, Teo P, Beasley MB, Leboeuf M, Becker CD, See P, Price J, Lucas D, Greter M, Mortha A, Boyer SW, Forsberg EC, Tanaka M, van Rooijen N, García-Sastre A, Stanley ER, Ginhoux F, Frenette PS, Merad M. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity. 2013, 38: 792-804.
  15. Chow A, Huggins M, Ahmed J, Hashimoto D, Lucas D, Kunisaki Y, Pinho S, Leboeuf M, Noizat C, van Rooijen N, Tanaka M, Zhao ZJ, Bergman A, Merad M, Frenette PS. CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nat Med. 2013, 19: 429-36.
  16. Helft J, Manicassamy B, Guermonprez P, Hashimoto D, Silvin A, Agudo J, Brown BD, Schmolke M, Miller JC, Leboeuf M, Murphy KM, García-Sastre A, Merad M. Cross-presenting CD103+ dendritic cells are protected from influenza virus infection. J Clin Invest. 2012, 122: 4037-47.
  17. Benoist C, Lanier L, Merad M, Mathis D; Immunological Genome Project. Consortium biology in immunology: the perspective from the Immunological Genome Project. Nat Rev Immunol. 2012, 12: 734-40.
  18. Scheiermann C, Kunisaki Y, Lucas D, Chow A, Jang JE, Zhang D, Hashimoto D, Merad M, Frenette PS. Adrenergic nerves govern circadian leukocyte recruitment to tissues. Immunity. 2012, 37: 290-301.
  19. Miller JC, Brown BD, Shay T, Gautier EL, Jojic V, Cohain A, Pandey G, Leboeuf M, Elpek KG, Helft J, Hashimoto D, Chow A, Price J, Greter M, Bogunovic M, Bellemare-Pelletier A, Frenette PS, Randolph GJ, Turley SJ, Merad M; Immunological Genome Consortium. Deciphering the transcriptional network of the dendritic cell lineage. Nat Immunol. 2012, 13: 888-99.
  20. Greter M, Helft J, Chow A, Hashimoto D, Mortha A, Agudo-Cantero J, Bogunovic M, Gautier EL, Miller J, Leboeuf M, Lu G, Aloman C, Brown BD, Pollard JW, Xiong H, Randolph GJ, Chipuk JE, Frenette PS, Merad M. GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells. Immunity. 2012, 36: 1031-46.
  21. Kwan WH, Hashimoto D, Paz-Artal E, Ostrow K, Greter M, Raedler H, Medof ME, Merad M, Heeger PS. Antigen-presenting cell-derived complement modulates graft-versus-host disease. J Clin Invest. 2012, 122: 2234-8.
  22. Singh G, Hashimoto D, Yan X, Helft J, Park PJ, Ma G, Qiao RF, Kennedy CR, Chen SH, Merad M, Chan AM. R-Ras is required for murine dendritic cell maturation and CD4+ T-cell priming. Blood. 2012, 119: 1693-701.
  23. Hashimoto D, Miller J, Merad M. Dendritic cell and macrophage heterogeneity in vivo. Immunity. 2011, 35: 323-35.
  24. Hashimoto D, Chow A, Greter M, Saenger Y, Kwan WH, Leboeuf M, Ginhoux F, Ochando JC, Kunisaki Y, van Rooijen N, Liu C, Teshima T, Heeger PS, Stanley ER, Frenette PS, Merad M. Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation. J Exp Med. 2011, 208: 1069-1082.
  25. Hashimoto D and Merad M. Harnessing dendritic cells to improve allogeneic hematopoietic cell transplantation outcome. Semin Immunol. 2011, 23: 50-57.
  26. Chow A, Lucas D, Hidalgo A, Méndez-Ferrer S, Hashimoto D, Scheiermann C, Battista M, Leboeuf M, Prophete C, van Rooijen N, Tanaka M, Merad M, Frenette PS. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med. 2011, 208: 261-271.
  27. Garcia MR, Ledgerwood L, Yang Y, Xu J, Lal G, Burrell B, Ma G, Hashimoto D, Li Y, Boros P, Grisotto M, van Rooijen N, Matesanz R, Tacke F, Ginhoux F, Ding Y, Chen SH, Randolph G, Merad M, Bromberg JS, Ochando JC. Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice. J Clin Invest. 2010, 120: 2486-2496
  28. Asakura S, Hashimoto D, Takashima S, Sugiyama H, Maeda Y, Akashi K, Tanimoto M, Teshima T. Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice. J Clin Invest. 2010, 120: 2370-2378.

 

[日本語論文]

  1. 橋本大吾. マクロファージは末梢組織でも自己増殖する?! 炎症と免疫. 22(6): 411-415, 2014.
  2. 早瀬英子, 橋本大吾, 豊嶋崇徳. 造血幹細胞移植後GVHD と消化管傷害. 最新医学 69(3): 503–507, 2014
  3. 橋本大吾. 免疫学からみた造血幹細胞移植. 細胞. 45 (11): 512-515, 2013.
  4. 橋本大吾, 豊嶋崇徳. 血球トラフィッキングと 血液フロンティア. 23(10): 59-69, 2013.
  5. 橋本大吾: M-CSFとマクロファージを利用した同種造血幹細胞移植後のGVHD予防. 今日の移植 25: 391-396, 2012
  6. 朝倉昇司, 橋本大吾, 高嶋秀一郎, 杉山暖子, 前田嘉信, 赤司浩一, 谷本光音, 豊嶋崇徳. 同種抗原による移植片対白血病効果減弱のメカニズム、岡山医学会雑誌. 124: 5-8, 2012

 

[国際学会]

  1. Hashimoto D, Tissue Resident Macrophages Self-maintain Locally Throughout Adult Life with Minimal Contribution from Circulating Monocytes. The 22nd International Symposium on Molecular Cell Biology of Macrophages, Jun 2-3, 2014, Kobe, Japan (Symposium)
  2. Shimoji S, Hashimoto D, Kato K, Tujigiwa H, Akashi K, Teshima T. Graft-Versus-Host Disease Targets Granulosa Cell of Ovarian Follicle and Causes Infertility after Allogeneic Hematopoietic Stem Cell Transplantation. 2015 BMT Tandem Meetings, Feb 11-15, San Diego, USA (Oral Presentation, The Best Abstract Award)
  3. Shimoji S, Kato K, Tsujigiwa H, Eriguchi Y, Lee L, Uryu H, Takashima S, Hashimoto D, Akashi K, Teshima T. Graft-Versus-Host Disease targets ovary and causes infertility after allo-HSCT. The 76th Annual Meeting of the Japanese Society of Hematology, Oct 31-Nov 2, 2014, Osaka, Japan (Oral Presentation)
  4. Hashimoto D. The biology of tissue resident macrophages. 1st meeting of Japan-Australia Hematology Consortium, Sep 14, 2014, Sapporo Japan. (Oral Presentation)
  5. Shimoji S, Kato K,Tsujigiwa H, Eriguchi Y, Lee L, Uryu H, Takashima S, Hashimoto D, Akashi K, Teshima T. Graft-Versus-Host Disease Targets Ovary and Causes Infertility After Allogeneic Hematopoietic Stem Cell Transplantation. 55th ASH Annual Meetin Dec 9th, 2013, New Orleans, USA.
  6. Hashimoto D, Chow A, Teo P, Beasley, M, See P, Lucas D, Boyer S, Forsberg EC, Tanaka M, Stanley ER, Ginhoux F, Frenette P, Merad M: Tissue resident macrophages do not derive from circulating monocytes in the steady state and after cell turnover. Keystone Symposia on Molecular and Cellular Biology. Myeloid Cells: Regulation and Inflammation. Keystone, CO, USA. February 19-24, 2013
  7. Chow A, Huggins M, Ahmed J, Lucas D, Hashimoto D, Kunisaki Y, Pinho S, Leboeuf M, Noizat C, van Rooijen N, Tanaka M, Zhao ZJ, Bergman A, Merad M, Frenette PS: CD169+ Macrophages Regulate Erythropoiesis Under Homeostasis, Recovery From Erythron Injury and in JAK2V617F-Induced Polycythemia Vera, The American Society of Hematology 54th Annual Meeting (Oral presentation), Atlanta, GA, USA. December 8-11, 2012
  8. Kwan WH, Hashimoto D, Paz-Artal E, Ostrow K, Greter M, Merad M and Heeger PS: Dendritic Cell Derived C3a/C5a Mediate Murine Graft Versus Host Disease. American Transplant Congress (Oral presentation), Philadelphia, PA, USA. April 30- May 4, 2011
  9. Saenger Y, Pan M, Hashimoto D, Glodny B, Shah S, Merghoub T, Wolchok J, Lebwohl M and Merad M: Anti-tyrosinase related protein 1 antibody in combination with cyclophosphamide enhances immunogenicity of established b16 melanoma. Annual Meeting of the Society for Investigative Dermatology, Phoenix, AZ, USA. May 4-7, 2011
  10. Hashimoto D, Chow A, Greter M, Leboeuf M, Ginhoux F, Teshima T and Merad M: Pre-Transplant CSF-1 Therapy Expands the Recipient Macrophage Pool and Modulates Graft Versus Host Disease After Allogeneic Hematopoietic Cell Transplantation, The American Society of Hematology 52nd Annual Meeting (Oral presentation), Orlando, FL, USA. December 4 – 7, 2010
  11. Takashima S, Aoyama K, Koyama M, Hashimoto D, Oshima T, Tomizuka K, Akashi K, and Teshima T: Protection of the Intestinal Epithelium from Conditioning with R-spondin1 Ameliorates Graft-Versus-Host Disease. The American Society of Hematology 50th Annual Meeting (Oral presentation), San Francisco, CA, USA. December 6-9, 2008

[国内学会]

  1. Hashimoto D, Teshima T. Key players in intestinal GVHD. The 76th Annual Meeting of the Japanese Society of Hematology, Oct 31-Nov 2, 2014, Osaka, Japan   (Symposium)
  2. 橋本大吾, Arthur Mortha, 豊嶋崇徳, Miriam Merad. CSF-1/CSF-2による炎症性疾患制御. 第79回日本インターフェロンサイトカイン学会. 2014年6月19日-20日, 札幌

[班会議発表]

  1. 早瀬英子,橋本大吾,豊嶋崇徳: Wntシグナルによる腸内細菌叢制御のメカニズムと治療応用.ゲノム支援2014年度拡大班会議. 2014年8月20日-21日, 神戸
  2. 橋本大吾, 豊嶋崇徳. 臍帯血移植における拒絶のメカニズム. 村田班 H25年度第2回合同班会議. 東京. 2014年1月11日, 口頭発表

[招聘講演等]

  1. 橋本大吾. マクロファージによる生体恒常性の維持. 第15回 さくら造血細胞セミナー. 2014年6月12日, 東京
  2. 橋本大吾. マクロファージはどこからやって来た?! 3回 Tenure Track Mixer. 2014年7月3日, 札幌
  3. 橋本大吾. 組織常在性マクロファーシジによる生体恒常性の維持. 第12回北大若手研究者交流会. 2014年8月8日 札幌. (招待講演)
  4. 橋本大吾, マクロファージの骨髄造血非依存性の証明. ブリストル血液学アカデミー, 2013年9月13日, 福岡.
  5. 橋本大吾, マクロファージの骨髄造血非依存性の証明. ヤクルト 第19回血液科学セミナー2013年11月9日, 東京.

[著書]

橋本大吾. 自然免疫とGVHD. みんなに役立つGVHDの基礎と臨床 7章: 86-92, 医薬ジャーナル社. 2013年9月.